The Southern Nevada Health District’s Wastewater Weekly Surveillance Report highlights the changes in wastewater concentration for selected pathogens within Clark County, Nevada. The reports include data for SARS CoV-2, Influenza (Flu) A, Influenza (Flu) B, Respiratory syncytial virus (RSV), Measles, Norovirus, and Mpox (clade II). All data was obtained from the Clark County Water Reclamation District, Flamingo Water Resource Center, City of Mesquite, selected Utah wastewater treatment facilities and California wastewater treatment facilities and is analyzed and reported by Wastewater Scan (https://www.wastewaterscan.org/en) and Verily laboratories (https://verily.com/).